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Fig. 4 | Molecular Cancer

Fig. 4

From: RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

Fig. 4

ALKBH5 inhibits tumour growth and invasion potential of PC models. a-c Xenografts derived from BxPC-3/Lv-ALKBH5 cells (ALKBH5 overexpression) demonstrated tumour weight b and volume a, c that were much lower than those of BxPC-3/vector-derived ones (empty). d-f However, xenografts generated from SW1990/shALKBH5 cells (ALKBH5 knockdown) exhibited a significant increase in tumour weight e and volume growth d, f when compared to those of SW1990/scramble-generated tumours (nude). g-h Immunohistochemical labelling showed the downregulated expression of ki-67 after ALKBH5 overexpression g and the upregulation of ki-67 after ALKBH5 knockdown h. i-j Immunohistochemical labelling showed the downregulated expression of MMP-2 and MMP-9 after ALKBH5 overexpression i and the upregulation of both MMPs after ALKBH5 knockdown j. k-l Luciferase activities verified the decreased and increased tumour growth, respectively, in orthotopic PC models established by BxPC-3/Lv-ALKBH5 cells k and SW1990/shALKBH5 cells l. *P < 0.05, **P < 0.01, and ***P < 0.001

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