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Fig. 5 | Molecular Cancer

Fig. 5

From: RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

Fig. 5

m6A methylation underlies the effects of ALKBH5. a Motif analysis using the program HOMER identified “GGACT” as the m6A consensus motif of BxPC-3 cells. b m6A-seq determined the number of m6A peaks in PC cells in the vector and Lv-ALKBH5 BxPC-3 groups. c m6A-seq determined the number of m6A-modified transcripts in both groups. d Distribution of total and unique m6A peaks in both groups is shown. e Bioinformatic analysis filtered PER1 as a downstream target of ALKBH5. f An m6A modification site in the 3′-UTR of PER1 mRNA was close to the YTHDF2 binding site. ALKBH5 overexpression abolished m6A modification of PER1 mRNA in BxPC-3 cells

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Molecular Cancer

ISSN: 1476-4598