Fig. 8
From: CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification
A Schematic Model of CircMRPS35 in the Proliferation and Metastasis of Gastric Cancer. In this model, circMRPS35 alters the histone modification pattern via recruiting KAT7 to FOXO1 and FOXO3a gene promoter regions as a modular scaffold, thereby increasing H4K5 acetylation in their promoter regions, which ultimately alters the downstream genes p21, p27, Twist1 and E-cadherin expression and suppresses the proliferation and invasion of gastric cancer cells