TY - JOUR AU - Jin, Dan AU - Guo, Jiwei AU - Wu, Yan AU - Yang, Lijuan AU - Wang, Xiaohong AU - Du, Jing AU - Dai, Juanjuan AU - Chen, Weiwei AU - Gong, Kaikai AU - Miao, Shuang AU - Li, Xuelin AU - Sun, Hongliang PY - 2020 DA - 2020/02/27 TI - m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC JO - Molecular Cancer SP - 40 VL - 19 IS - 1 AB - The importance of mRNA methylation erased by ALKBH5 in mRNA biogenesis, decay, and translation control is an emerging research focus. Ectopically activated YAP is associated with the development of many human cancers. However, the mechanism whereby ALKBH5 regulates YAP expression and activity to inhibit NSCLC tumor growth and metastasis is not clear. SN - 1476-4598 UR - https://doi.org/10.1186/s12943-020-01161-1 DO - 10.1186/s12943-020-01161-1 ID - Jin2020 ER -