Table 1 LncRNAs-induced cell death in drug - resistant cancer cells
From: Long non-coding RNAs regulate drug resistance in cancer
LncRNA | Cancer type | Drug resistant | Mechanisms | Ref |
|---|---|---|---|---|
ERIC | Osteosarcoma | Etoposide | ERIC inhibits DNA damage-induced apoptosis | [34] |
PDAM | Oligodendroglial tumor | Cisplatin | Loss of PDAM inhibits apoptosis by increasing the expression of BCL-2 | [35] |
PCGEM1 | Prostate cancer | DOX | Overexpression of PCGEM1 inhibits apoptosis by suppressing the activation of caspase 7 | [36] |
CUDR | Bladder cancer | Cisplatin | Overexpression of CUDR suppresses DNA damage-induced apoptosis | [37] |
DDSR1 | Non-small cell lung cancer | Cisplatin | DDSR1 inhibits DNA damage-induced apoptosis by promoting DNA repair with homologous recombination | [43] |
HOTAIR | Non-small cell lung cancer | Cisplatin | HOTAIR contributes to cisplatin resistance via downregulation of P21 | [58] |
SCAL1 | Non-small cell lung cancer | Gefitinib | SCAL1 is overexpressed in lung cancer cells with elevated expression of NrF2 |