Table 2 Drug targets and EMT related lncRNAs in anti-cancer drug resistance
From: Long non-coding RNAs regulate drug resistance in cancer
lncRNAs | Up/down | Targets | Mechanisms and function | Cancers | Refs |
|---|---|---|---|---|---|
lncRNA LBCS | up | AR | AR activation | PCa | [73] |
HOXC-AS3 | up | H3K4me3 and H3K27 | By YBX1 regulating, promotes H3K4me3 and H3K27 acetylation | GC | [97] |
miR503HG | Down | Â | Â | HCC | [84] |
HOTAIR | up | Â | Â | PCa | [75] |
CCAT1 | up | EGFR | TP63 and SOX2 co-bind to the promoter and super-enhancer regions of CCAT1 | SCC | [85] |
URRCC | up | EGFL7/P-AKT/FOXO3 | AKT signaling pathway Proliferation and metastasis | RCC | [88] |
lncRNA GUARDIN | up | TRF2 | p53-responsive lncRNA | Various cancers | [98] |
Linc00210 | up | CTNNBIP1 | Wnt/β-catenin signaling activation | liver cancer | [99] |
Linc00659 | up | cycle-related genes | Â | colorectal cancer | [100] |
LINC01133 | up | APC | Wnt/β-catenin pathway | gastric cancer | [101] |