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Table 2 Drug targets and EMT related lncRNAs in anti-cancer drug resistance

From: Long non-coding RNAs regulate drug resistance in cancer

lncRNAsUp/downTargetsMechanisms and functionCancersRefs
lncRNA LBCSupARAR activationPCa[73]
HOXC-AS3upH3K4me3 and H3K27By YBX1 regulating, promotes H3K4me3 and H3K27 acetylationGC[97]
miR503HGDown  HCC[84]
HOTAIRup  PCa[75]
CCAT1upEGFRTP63 and SOX2 co-bind to the promoter and super-enhancer regions of CCAT1SCC[85]
URRCCupEGFL7/P-AKT/FOXO3AKT signaling pathway
Proliferation and metastasis
RCC[88]
lncRNA
GUARDIN
upTRF2p53-responsive lncRNAVarious cancers[98]
Linc00210upCTNNBIP1Wnt/β-catenin signaling activationliver cancer[99]
Linc00659upcycle-related genes colorectal cancer[100]
LINC01133upAPCWnt/β-catenin pathwaygastric cancer[101]