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Fig. 5 | Molecular Cancer

Fig. 5

From: CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

Fig. 5

M2-polorization of TAMs is associated with depletion of antitumor effector T cells in ESCC carcinogenesis. a and c) Flow cytometry shows inhibition of TAMs (CD11b+F4/80+) accumulation as well as M2 polarization (F4/80+CD206+) by CCR2 knockout. Data is shown by mean ± standard deviation (n = 6). b and d CCR2 knockout increases antitumor effector T cells (CD3+CD8+ CTLs) in tumors (n = 6). e and f CCL2 deletion inhibits TAMs M2-polorization (e) and antitumor effector T cells depletion (f) during carcinogenesis (n = 5). g Representative IHC staining indicates expression of CCL2 inversely correlated with CD8 (effector T cells) in human ESCC cohort II (n = 100)

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Molecular Cancer

ISSN: 1476-4598