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Fig. 2 | Molecular Cancer

Fig. 2

From: mRNA modification orchestrates cancer stem cell fate decisions

Fig. 2

Roles of m5C RNA modifications in cancer. DNMT2 and NSUN2 are RNA methyltransferases responsible for m5C modification. The m5C reader protein ALYREF recognizes m5C- methylated mRNA and initiates transportation from nucleus towards cytoplasm. In bladder cancer, HDGF mRNA is methylated and captured by reader protein YBX1. By interacting with YBX1, HuR stabilizes HDGF mRNA and induces tumor metastasis

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Molecular Cancer

ISSN: 1476-4598