Fig. 1
From: CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer
ALOX15 is related to ferroptosis in gastric cancer. a. Mass spectrum analysis of gene expression changes in gastric tumor tissues (n = 45). The heatmap depicts the relative protein abundance in tumor tissues (T) and paired para-carcinoma tissues (P). b. Validation of ALOX15 dys-regulation in GC by using western blotting analysis (n = 12). c. Quantitative analysis of (b) (n = 12). d. Relative levels of ALOX15 mRNA in gastric tumor tissues (n = 12). e. Analysis of ALOX15 distribution in tumor tissues by using IHC (n = 12). f. High expression of ALOX15 predicts poor overall survival in GC. Patients were divided into ALOX15 high group (n = 77) and ALOX15 low group (n = 86) base on the average value of ALOX15 protein levels. g. Relative levels of lipid-ROS levels in gastric tumor tissues (n = 12). h. ALOX15 is positively co-related with Lipid-ROS production (n = 12). ** indicates p < 0.01