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Table 1 Representative clinical trials concerning metabolic regulation in pancreatic cancer

From: Metabolism of pancreatic cancer: paving the way to better anticancer strategies

NCT NumberStatusPhaseTumor TypesInterventionsMonotherapy/Combination
Targets: Glycolysis and Mitochondrial Metabolism
 NCT00096707CompletedILung Cancer
Breast Cancer
Pancreatic Cancer
Head and Neck Cancer
Gastric Cancer
2-DG ± DocetaxelMonotherapy/Combination
 NCT01835041Active, Not RecruitingIAcinar Cell Adenocarcinoma of the Pancreas,
Duct Cell Adenocarcinoma of the Pancreas,
Recurrent Pancreatic Cancer,
Stage IV Pancreatic Cancer
CPI-613 + mFOLFIRINOXCombination
 NCT01419483TerminatedN/APancreatic NeoplasmsKetogenic DietN/A
Targets: Amino Acids Metabolism and Redox Balance
 NCT02514031RecruitingIPancreatic CancerARQ-761 + Gemcitabine + Nab-paclitaxelCombination
 NCT01523808CompletedIPancreatic CancerGRASPAMonotherapy
 NCT02195180CompletedIIMetastatic Pancreatic AdenocarcinomaERY001 + Gemcitabine or FOLFOXCombination
 NCT02077881CompletedI/IIMetastatic Pancreatic Adenocarcinoma,
Metastatic Pancreatic Cancer
Indoximod + Gemcitabine + Nab-paclitaxelCombination
 NCT03006302RecruitingIIMetastatic Pancreatic AdenocarcinomaEpacadostat + Pembrolizumab + CRS-207 ± Cyclophosphamide/GVAXCombination
 NCT01049880CompletedIPancreatic NeoplasmsGemcitabine + Ascorbic AcidCombination
Target: Lipids Metabolism
 NCT00944463CompletedIIPancreatic CancerGemcitabine + SimvastatinCombination
 NCT01019382CompletedIIPancreatic NeoplasmsGemcitabine + Lipidem Fish Oil InfusionCombination
 NCT03073785RecruitingIIPancreatic Adenocarcinoma
Recurrent Pancreatic Carcinoma
Stage I Pancreatic Cancer AJCC v6 and v7
Stage IA Pancreatic Cancer AJCC v6 and v7
Stage IB Pancreatic Cancer AJCC v6 and v7
Stage II Pancreatic Cancer AJCC v6 and v7
Stage IIA Pancreatic Cancer AJCC v6 and v7
Stage IIB Pancreatic Cancer AJCC v6 and v7
Stage III Pancreatic Cancer AJCC v6 and v7
Stage IV Pancreatic Cancer AJCC v6 and v7
Zoledronic Acid + Capecitabine + Fluorouracil + Radiation TherapyCombination
Targets: Autophagy and Macropinocytosis
 NCT01777477CompletedIPancreatic CancerGemcitabine + ChloroquineCombination
 NCT03825289RecruitingIMetastatic Pancreatic Carcinoma
Stage II Pancreatic Cancer
Stage IIA Pancreatic Cancer
Stage IIB Pancreatic Cancer
Stage III Pancreatic Cancer
Stage IV Pancreatic Cancer
Unresectable Pancreatic Carcinoma
Hydroxychloroquine + TrametinibCombination
Target: mTOR
 NCT00409292CompletedIIPancreatic CancerRAD001Monotherapy
 NCT00593008TerminatedIPancreatic AdenocarcinomaGemcitabine + TemsirolimusCombination
 NCT01079702UnknownI/IIAdvanced Malignancies (Including Pancreatic Cancer)Capecitabine + EverolimusCombination
Comprehensive Metabolic Regulation
 NCT03889795RecruitingIAdvanced Pancreatic Cancer
Advanced Solid Tumor
Metformin + Simvastatin + DigoxinCombination
 NCT02201381RecruitingIIICancer (Including Pancreatic Cancer)Metabolic Treatment (Metformin + Atorvastatin + Doxycycline + Mebendazole)Combination
 NCT02048384Active, Not RecruitingI/IIMetastatic Pancreatic AdenocarcinomaMetformin ± RapamycinMonotherapy/Combination