Skip to main content

Table 1 Representative clinical trials concerning metabolic regulation in pancreatic cancer

From: Metabolism of pancreatic cancer: paving the way to better anticancer strategies

NCT Number

Status

Phase

Tumor Types

Interventions

Monotherapy/Combination

Targets: Glycolysis and Mitochondrial Metabolism

 NCT00096707

Completed

I

Lung Cancer

Breast Cancer

Pancreatic Cancer

Head and Neck Cancer

Gastric Cancer

2-DG ± Docetaxel

Monotherapy/Combination

 NCT01835041

Active, Not Recruiting

I

Acinar Cell Adenocarcinoma of the Pancreas,

Duct Cell Adenocarcinoma of the Pancreas,

Recurrent Pancreatic Cancer,

Stage IV Pancreatic Cancer

CPI-613 + mFOLFIRINOX

Combination

 NCT01419483

Terminated

N/A

Pancreatic Neoplasms

Ketogenic Diet

N/A

Targets: Amino Acids Metabolism and Redox Balance

 NCT02514031

Recruiting

I

Pancreatic Cancer

ARQ-761 + Gemcitabine + Nab-paclitaxel

Combination

 NCT01523808

Completed

I

Pancreatic Cancer

GRASPA

Monotherapy

 NCT02195180

Completed

II

Metastatic Pancreatic Adenocarcinoma

ERY001 + Gemcitabine or FOLFOX

Combination

 NCT02077881

Completed

I/II

Metastatic Pancreatic Adenocarcinoma,

Metastatic Pancreatic Cancer

Indoximod + Gemcitabine + Nab-paclitaxel

Combination

 NCT03006302

Recruiting

II

Metastatic Pancreatic Adenocarcinoma

Epacadostat + Pembrolizumab + CRS-207 ± Cyclophosphamide/GVAX

Combination

 NCT01049880

Completed

I

Pancreatic Neoplasms

Gemcitabine + Ascorbic Acid

Combination

Target: Lipids Metabolism

 NCT00944463

Completed

II

Pancreatic Cancer

Gemcitabine + Simvastatin

Combination

 NCT01019382

Completed

II

Pancreatic Neoplasms

Gemcitabine + Lipidem Fish Oil Infusion

Combination

 NCT03073785

Recruiting

II

Pancreatic Adenocarcinoma

Recurrent Pancreatic Carcinoma

Stage I Pancreatic Cancer AJCC v6 and v7

Stage IA Pancreatic Cancer AJCC v6 and v7

Stage IB Pancreatic Cancer AJCC v6 and v7

Stage II Pancreatic Cancer AJCC v6 and v7

Stage IIA Pancreatic Cancer AJCC v6 and v7

Stage IIB Pancreatic Cancer AJCC v6 and v7

Stage III Pancreatic Cancer AJCC v6 and v7

Stage IV Pancreatic Cancer AJCC v6 and v7

Zoledronic Acid + Capecitabine + Fluorouracil + Radiation Therapy

Combination

Targets: Autophagy and Macropinocytosis

 NCT01777477

Completed

I

Pancreatic Cancer

Gemcitabine + Chloroquine

Combination

 NCT03825289

Recruiting

I

Metastatic Pancreatic Carcinoma

Stage II Pancreatic Cancer

Stage IIA Pancreatic Cancer

Stage IIB Pancreatic Cancer

Stage III Pancreatic Cancer

Stage IV Pancreatic Cancer

Unresectable Pancreatic Carcinoma

Hydroxychloroquine + Trametinib

Combination

Target: mTOR

 NCT00409292

Completed

II

Pancreatic Cancer

RAD001

Monotherapy

 NCT00593008

Terminated

I

Pancreatic Adenocarcinoma

Gemcitabine + Temsirolimus

Combination

 NCT01079702

Unknown

I/II

Advanced Malignancies (Including Pancreatic Cancer)

Capecitabine + Everolimus

Combination

Comprehensive Metabolic Regulation

 NCT03889795

Recruiting

I

Advanced Pancreatic Cancer

Advanced Solid Tumor

Metformin + Simvastatin + Digoxin

Combination

 NCT02201381

Recruiting

III

Cancer (Including Pancreatic Cancer)

Metabolic Treatment (Metformin + Atorvastatin + Doxycycline + Mebendazole)

Combination

 NCT02048384

Active, Not Recruiting

I/II

Metastatic Pancreatic Adenocarcinoma

Metformin ± Rapamycin

Monotherapy/Combination