Fig. 1

Landscape of genetic and expression variation of m⁶A regulators in gastric cancer. a Summary of the dynamic reversible process of m⁶A RNA methylation mediated by regulators (“writers”, “erasers” and “readers”) and their potential biological functions for RNA. b The mutation frequency of 21 m⁶A regulators in 433 patients with gastric cancer from TCGA-STAD cohort. Each column represented individual patients. The upper barplot showed TMB, The number on the right indicated the mutation frequency in each regulator. The right barplot showed the proportion of each variant type. The stacked barplot below showed fraction of conversions in each sample. c The CNV variation frequency of m⁶A regulators in GSE62717 cohort. The height of the column represented the alteration frequency. The deletion frequency, blue dot; The amplification frequency, red dot. d The location of CNV alteration of m⁶A regulators on 23 chromosomes using GSE62717 cohort. e Principal component analysis for the expression profiles of 21 m⁶A regulators to distinguish tumors from normal samples in GSE2269 cohort. Two subgroups without intersection were identified, indicating the tumors and normal samples were well distinguished based on the expression profiles of m⁶A regulators. Tumors were marked with blue and normal samples marked with yellow. f The expression of 21 m⁶A regulators between normal tissues and gastric tissues. Tumor, red; Normal, blue. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value, and black dots showed outliers. The asterisks represented the statistical p value (*P < 0.05; **P < 0.01; ***P < 0.001)