Fig. 3
TME cell infiltration characteristics and transcriptome traits in distinct m6A modification patterns. a The abundance of each TME infiltrating cell in three m6A modification patterns. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value, and black dots showed outliers. The asterisks represented the statistical p value (*P < 0.05; **P < 0.01; ***P < 0.001). b Differences in stroma-activated pathways including EMT, TGF beta and angiogenesis pathways among three distinct m6A modification patterns. The statistical differences among three modification patterns was tested by the one-way ANOVA test. The asterisks represented the statistical p value (*P < 0.05; **P < 0.01; ***P < 0.001). c Unsupervised clustering of 21 m6A regulators in the ACRG gastric cancer cohort. The m6Acluster, ACRG molecular subtypes, tumor stage, survival status and age were used as patient annotations. Yellow represented high expression of regulators and blue represented low expression. d Principal component analysis for the transcriptome profiles of three m6A modification patterns, showing a remarkable difference on transcriptome between different modification patterns. e The proportion of ACRG molecular subtypes in the three modification patterns. MSI subtype, red; EMT subtype, blue; MSS/TP53+ subtype, green; MSS/TP53- subtype, yellow. f Functional annotation for m6A-related genes using GO enrichment analysis. The color depth of the barplots represented the number of genes enriched