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Table 2 Cancer radioresistance related miRNAs

From: Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

CancersmiRNAsTargets/MechanismsReferences
Prostate cancermiR-205Disturbing DNA damage repair through PKCε and ZEB1 inhibition[149]
miR-875-5pRegulating EMT; Suppressing EGFR-ZEB1 axis[150]
miR-124/ miR-144Counteracting hypoxia-induced autophagy and downregulating PIM1[151]
miR-301a/miR-301bRegulating miR-301a/b-NDRG2 axis[152]
Esophageal cancermiR-193a-3pReducing PSEN1[153]
miR-301aTargeting WNT1, counteracting the Wnt/ β-catenin signaling pathway and reversing EMT[154]
miR-338-5pRegulating survivin[155]
miR-17Regulating C6orf120[156]
miR-98Binding to BCL-2[157]
miR-124Regulating miR-124/ CDK4 axis[158]
Nasopharyngeal carcinomamiR-495Binding the 3’UTR of GRP78 and inhibiting its expression[159]
miR-24-3pModulating 3’UTR and 5’UTR of Jab1/CSN5[160]
miR-24Binding SP1[161]
miR-150Inhibiting GSK3β[162]
miR-222Interacting with PTEN[163]
miR-19b-3pActivating TNFAIP3/NF-κB pathway[164]
Cervical cancermiR-4778-3pNegatively regulating NR2C2 and Med19 expression; Enhancing apoptosis-related genes expression[165]
miR-15a-3pPromoting tumor protein D52[166]
miR-125Downregulating CDKN1A and targeting p21[167]
miR-424Targeting aprataxin[168]
miR-21Decreasing PTEN and increasing p-Akt/HIF-1α; Inhibiting autophagy via Akt-mTOR pathway[169]
Lung cancermiR-198Inhibiting HGF/c-MET pathway[170]
miR-99aBinding to mTOR[171]
miR-558Associating with AATK[172]
miR-148bModulating MutL homologue 1[173]
miR-335Reducing the expression of PARP-1, downregulating NF-κB[174]
miR-1246Inhibiting DR5[175]
miR-21Upregulating HIF-1α[176]
miR-208aTargeting p21 with a corresponding activation of the Akt/mTOR pathway[177]
Oral cancer stem cellsmiR-218Activating miR-218/Bmi1 axis[178]
Hepatocellular carcinomamiR-92bReducing p57kip2 expression[179]
Breast cancermiR-142-3pAttenuating CSCs characteristics and inhibiting β-catenin expression[180]
miR-22Negatively modulating Sirt1[181]
miR-668Forming miR-668/ IκBα/NF-κB axis[182]
Ovarian cancermiR-214Depressing PETN and consequently activating PI3K/Akt pathway[183]