TY - JOUR AU - Jin, Bei AU - Zhang, Ping AU - Zou, Hailin AU - Ye, Huijing AU - Wang, Yun AU - Zhang, Jing AU - Yang, Huasheng AU - Pan, Jingxuan PY - 2020 DA - 2020/03/04 TI - Verification of EZH2 as a druggable target in metastatic uveal melanoma JO - Molecular Cancer SP - 52 VL - 19 IS - 1 AB - Hepatic metastasis develops in ~ 50% of uveal melanoma (UM) patients with no effective treatments. Although GNAQ/GNA11 mutations are believed to confer pathogenesis of UM, the underlying mechanism of liver metastasis remains poorly understood. Given that profound epigenetic evolution may occur in the long journey of circulating tumor cells (CTCs) to distant organs, we hypothesized that EZH2 endowed tumor cells with enhanced malignant features (e.g., stemness and motility) during hepatic metastasis in UM. We aimed to test this hypothesis and explore whether EZH2 was a therapeutic target for hepatic metastatic UM patients. SN - 1476-4598 UR - https://doi.org/10.1186/s12943-020-01173-x DO - 10.1186/s12943-020-01173-x ID - Jin2020 ER -