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Table 1 Roles of ncRNAs implicated in leukemia

From: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Type of ncRNA ncRNA Type of leukemia Expression in leukemia Mechanism/target/pathway References
miRNA miR-194-5p AML Upregulated inducing BCLAF1; BCL2-associated transcription factor 1 (BCLAF1) [18]
miRNA miR-103 AML Upregulated Blocking PI3K/AKT signal pathway by regulation of COP1 [19]
miRNA miR-15a CML-CP Upregulated Expression modulated by BCR–ABL is linked to CML progression and imatinib resistance [20]
miRNA miR-130b CML-CP Downregulated Expression modulated by BCR–ABL is linked to CML progression and imatinib resistance [20]
miRNA miR-145 CML-CP Upregulated Expression modulated by BCR–ABL is linked to CML progression and imatinib resistance [20]
miRNA miR-16 CML-CP Downregulated Expression modulated by BCR–ABL is linked to CML progression and imatinib resistance [20]
miRNA miR-26a CML-CP Downregulated Expression modulated by BCR–ABL is linked to CML progression and imatinib resistance [20]
miRNA miR-146a CML-CP Downregulated Expression modulated by BCR–ABL is linked to CML progression and imatinib resistance [20]
miRNA miR-29c CML-CP Downregulated Expression modulated by BCR–ABL is linked to CML progression and imatinib resistance [20]
miRNA miR-96 AML Downregulated Oncogene Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) knockdown inhibited proliferation, promoted apoptosis and enhanced Ara-C sensitivity in AML cells by upregulating miR-96 [21]
miRNA miR-128b ALL Downregulated downregulation of the MLL-AF4 chimeric fusion proteins MLL-AF4 and AF4-MLL that are generated by chromosomal translocation t(4;11) [22]
miRNA miR-34a AML Downregulated TUG1 confers Adriamycin resistance in acute myeloid leukemia by epigenetically suppressing miR-34a expression via EZH2 [23, 24]
miRNA miR-451a CML Downregulated NR [25]
miRNA let-7b-5p CML Downregulated NR [25]
miRNA hsa-miR-425 AML Upregulated Through calcium signaling pathway and natural killer cell mediated cytotoxicity. [26]
miRNA hsa-miR- 200c AML Downregulated NR [26, 27]
miRNA hsa-mir-30a CML Downregulated NR [28]
miRNA miRNA-155 ALL Upregulated NR [29]
miRNA miR-130a CML Downregulated Functions as a tumor suppressor by inhibiting multiple anti-apoptosis proteins, including BCL-2, MCL-1 and XIAP. [30]
miRNA miR-125b AML; ALL Upregulated microRNA125b promotes leukemia cell resistance to daunorubicin through inhibiting apoptosis [31]
miRNA miR-224 CML Downregulated miR-224, along with let-7i, regulate the proliferation and chemosensitivity of CML cells probably via targeting ST3GAL IV. [32]
lncRNA HOXA-AS2 AML Upregulated HOXA-AS2 negatively regulates the expression of miR-520c-3p in ADR cells. S100A4 was predicted as a downstream target of miR-520c-3p, [33]
lncRNA TUG1 AML Upregulated TUG1 confers Adriamycin resistance in acute myeloid leukemia by epigenetically suppressing miR-34a expression via EZH2 [23, 34]
lncRNA RP11-342 M1.7 AML Upregulated Involved in neoplastic signaling pathways [35]
lncRNA CDCA4P3 AML Upregulated Involved in neoplastic signaling pathways [35]
lncRNA CES1P1 AML Downregulated Involved in neoplastic signaling pathways [35]
lncRNA AC008753.6 AML Downregulated Involved in neoplastic signaling pathways [35]
lncRNA RP11-573G6.10 AML Downregulated Involved in neoplastic signaling pathways [35]
lncRNA MEG3 CML Downregulated contributes to imatinib resistance through regulating miR-21 [36]
lncRNA PANDAR AML Upregulated NR [37]
lncRNA GAS5 AML Upregulated Via affecting hematopoietic reconstitution [38]
lncRNA UCA1 CML Upregulated UCA1acts as a ceRNA Against miR-16 in Chronic Myeloid Leukemia Cells [39]
lncRNA MALAT1 CML Upregulated MALAT1 promotes imatinib resistance of CML cells by targeting miR-328 [40]
lncRNA UCA1 AML Upregulated knockdown of UCA1 plays a role in overcoming the chemoresistance of pediatric AML, by inhibiting glycolysis through regulating the miR-125a/HK2 pathway. [41]
lncRNA NONHSAT076891 APL Upregulated NR [42]
lncRNA CRNDE AML Upregulated NR [13]
lncRNA LINC00899 AML Upregulated NR [12]
lncRNA HOTAIR CML Upregulated Knockdown of HOTAIR expression downregulates MRP1 expression levels and reverses imatinib resistance via PI3K/Akt pathway. [43]
lncRNA IRAIN AML Downregulated Interaction with chromatin DNA and involvement in the formation of an intrachromosomal promoter loop [44]
lncRNA CCDC26 AML Upregulated NR [45]
lncRNA KCNQ1OT1 AML Upregulated NR [46]
lncRNA NONHSAT027612.2 ALL Upregulated Through regulating immune response-associated pathways. [47]
lncRNA NONHSAT134556.2 ALL Upregulated Through regulating immune response-associated pathways. [47]
lncRNA LINP1 AML Upregulated Via HNF4alpha/AMPK/WNT5A signaling pathway [48]
lncRNA SNHG3 AML Upregulated SNHG3 elicits a growth-promoting function in AML via sponging miR-758-3p to regulate SRGN expression [49]
lncRNA LUNAR1 ALL Downregulated Proliferation of T cells [50, 51]
lncRNA T-ALL-R-LncR1 ALL Upregulated Regulate apoptosis by Par-4/THAP1 protein complex [52]
lncRNA HOTAIRM1 AML Upregulated Chromatin modification, myeloid differentiation [53, 54]
lncRNA PVT1 AML Upregulated Oncogene, induce proliferation and suppress Apoptosis [55]
lncRNA ANRIL AML/ALL Upregulated Myeloblast proliferation [56]
lncRNA BGL3 CML Upregulated Apoptosis and DNA methylation [57]
circRNA f-circPR AML Upregulated High proliferation, chemo resistance, Differential expression [58]
circRNA circ-PVT1 AML Upregulated Involved in the development of leukaemia (AML) [59]
circRNA circNPM1 75,001 (hsa_circ_0075001) AML Upregulated NPM1/regulate myeloid differentiation though miR-181, [60]
circRNA circ-HIPK2 AML Downregulated Regulate differentiation though miR-124-3p [61]
circRNA circRNA-DLEU2 AML Upregulated Enhanced cell division, survival, and proliferation with suppressed apoptosis through miR-496/ PRKACB [62]
circRNA hsa_circ_0004277 AML Downregulated Act as prognostic factor for survival outcome in AML patients. Target multiple miRNAs and Genes miR-138-5p, miR-30c-1-3p, miR-892b, miR-571, miR-328-3p/SH3GL2, PPARGC1A, PIP4K2C, SH2B3, ZNF275, and ATP1B4 [63]
circRNA circ-CBFB CLL Upregulated regulating miR-607/FZD3/Wnt/beta-catenin pathway [64]
circRNA circ_0132266 CLL Downregulated circ_0132266 acts as a sponge of miR-337-3p and regulates its activity, resulting in a downstream change of target-gene PML, influencing cell viability. [65]
circRNA circPAN3 AML Upregulated circPAN3-miR-153-5p/miR-183-5p-XIAP axis; circPAN3 may facilitate AML drug resistance through regulating autophagy and influencing expression of apoptosis-related proteins [66, 67]
circRNA circ_0009910 AML Upregulated knockdown of circ_0009910 inhibited AML cell proliferation and induced apoptosis by acting as a sponge for miR-20a-5p [68]
circRNA circ_100053 CML Upregulated involved in imatinib resistance [69]
circRNA hsa_circ_0080145 CML Upregulated knockdown of hsa_circ_0080145 significantly suppressed CML cell proliferation thorugh acting as a sponge for miR-29b. [70]
circRNA circ-ANAPC7 AML Upregulated circ-ANAPC7 targets the MiR-181 Family [71]
circRNA hsa_circ_0004277 AML Downregulated Increasing level of hsa_circ_0004277 by chemotherapy was associated with successful AML treatment [63]
circRNA circBA9.3 CML Upregulated Chemoresistance, Oncogene, Induce cell proliferation and supressed apoptosis [72]
siRNA SKP2 AML Upregulated SKP2 inhibits the degradation of P27kip1 and down-regulates the expression of MRP [73]