Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

Cui, Chaochu; Yang, Jianbo; Li, Xiao; Liu, Dongling; Fu, Liwu; Wang, Xianwei

doi:10.1186/s12943-020-01180-y

Molecular Cancer

Table 2 Altered circRNAs in chemoresistant cancer cells

From: Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

System	Cancer	Number of alterations/name of circRNA	Alteration	Target	Related drugs	References
Musculoskeletal system	Osteosarcoma	hsa_circ_0001258	↓	miR-744-3p	Doxorubicin	[110]
		circ-LARP4	↓	miR-424	Cisplatin, doxorubicin	[111]
		has_circ_0004674	↑	–	Doxorubicin	[112]
		circPVT1	↑	–	Methotrexate, doxorubicin, cisplatin, ifosfamide	[40]
Respiratory System	Metastatic Nasopharyngeal carcinoma	circCRIM1	↑	miR-422a	Paclitaxel	[113]
	Lung cancer	7966	↑	–	Osimertinib	[114]
		7538	↓	–	Osimertinib	[114]
		2909	↑	–	Paclitaxel	[20]
		8372	↓	–	Paclitaxel	[20]
		circESRP1	↓	miR-93-5p	Doxorubicin, cisplatin, etoposide	[115]
		circ_0002483	↓	miR-182-5p	Paclitaxel	[116]
		hsa_circ_0004015	↑	miR-1183	Gefitinib	[117]
		circSETD3		miR-520 h	Gefitinib	[36]
		CCDC66		–	Cisplatin	[118]
		circ_0076305		miR-296-5p	Cisplatin	[119]
		circFGFR1		miR-3 81-3p	PD-1 antibody	[120]
		circPVT1		miR-145-5p	Cisplatin, pemetrexed	[41]
		ciRS-7		–	Pemetrexed, cisplatin	[121]
Hematopoietic system	Leukemia	circ_100053	↑	–	Imatinib	[122]
		circMYBL2		PTBP1 protein	Quizartinib	[24]
		crcPAN3		miR-153-5p and miR-183-5p	Doxorubicin	[123, 124]
		circBA9.3		–	Imatinib, nilotinib, dasatinib	[125]
		circ_0009910		miR-34a-5p	Imatinib	[126]
Endocrine system	Thyroid carcinoma	circEIF6	↑	miR-144-3p	Cisplatin	[79]
	Pancreatic cancer	chr14: 101402109–101464448+, chr4: 52729603–52780244+	↑	miR-145	Gemcitabine	[127]
		26	↑	–		[19]
		55	↓	–		[19]
	Cervical cancer	circMTO1	↑	miR-6893	Cisplatin	[128]
	Cervical cancer	hsa_circ_0023404	↑	miR-5047	Cisplatin	[129]
	Breast cancer	circ 0006528	↑	miR-7	Doxorubicin	[130]
		ciRS-7	↑	miR-7	Cisplatin, 5-FU, tamoxifen	[131,132,133]
		circRNA-MTO1	↓	TRAF4 protein	Monastrol	[134]
		hsa_circ_0025202		miR-182-5p	Tamoxifen	[135]
		circBMPR2		miR-553	Tamoxifen	[136]
		circKDM4C		miR-548p	Doxorubicin	[137]
Digestive system	Oral carcinoma	hsa_circ_0005379	↓	–	Cetuximab	[138]
	Hepatocellular carcinoma	circRNA_101505	↓	miR-103	Cisplatin	[31]
	Gastric cancer	hsa_circ_0000199	↑	miR-198	Cisplatin	[84]
		hsa_circ_0081143		miR-646		[139]
		circFN1		miR-182-5p		[140, 141]
		circPVT1		miR-124-3p	Paclitaxel	[141]
	Colorectal cancer	773	↑	–	5-FU and oxaliplatin	[142]
		732	↓			[142]
		34	↓			[29]
		105	↑			[29]
		circ_001680	↑	miR-340	Irinotecan	[46]
		ciRS-122	↑	miR-122	Oxaliplatin	[143]
Urinary system	Renal cancer	hsa_circ_0035483	↑	miR-335	Gemcitabine	[144]
	Bladder cancer	hsa_circ_0000285	↓	–	–	[145]
		ciRS-7	↓	miR-1270	Cisplatin	[95]
		circELP3	↑	–	–	[96]
	Prostate cancer	circRNA17	↓	miR-181c-5p	Enzalutamide	[146]
		588	↓	–		[147]
		278	↑	–		[147]
		hsa_circ_0022392 and hsa_circ_0000326	↓	–	–	[148]
		hsa_circ_0001275 and hsa_circ_0001721	↑	–	–	[148]
Reproductive system	Ovarian cancer	ciRS-7	↓	miR-1270	Cisplatin	[26]
Reproductive system	Ovarian cancer	circCELSR1	↑	miR-1252	Paclitaxel	[149]
Miscellaneous	Myeloma	hsa_circ_0007841	↑	–	–	[150]
Miscellaneous	Melanoma	ciRS-7	↓	–	–	[151]

Notes: ↑ means increased; ↓means decreased; −- means not reported yet

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