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Table 2 Altered circRNAs in chemoresistant cancer cells

From: Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance

SystemCancerNumber of alterations/name of circRNAAlterationTargetRelated drugsReferences
Musculoskeletal systemOsteosarcomahsa_circ_0001258miR-744-3pDoxorubicin[110]
circ-LARP4miR-424Cisplatin, doxorubicin[111]
has_circ_0004674Doxorubicin[112]
circPVT1Methotrexate, doxorubicin, cisplatin, ifosfamide[40]
Respiratory SystemMetastatic Nasopharyngeal carcinomacircCRIM1miR-422aPaclitaxel[113]
Lung cancer7966Osimertinib[114]
7538
2909Paclitaxel[20]
8372
circESRP1miR-93-5pDoxorubicin, cisplatin, etoposide[115]
circ_0002483miR-182-5pPaclitaxel[116]
hsa_circ_0004015miR-1183Gefitinib[117]
circSETD3miR-520 h[36]
CCDC66Cisplatin[118]
circ_0076305miR-296-5pCisplatin[119]
circFGFR1miR-3 81-3pPD-1 antibody[120]
circPVT1miR-145-5pCisplatin, pemetrexed[41]
ciRS-7Pemetrexed, cisplatin[121]
Hematopoietic systemLeukemiacirc_100053Imatinib[122]
circMYBL2PTBP1 proteinQuizartinib[24]
crcPAN3miR-153-5p and miR-183-5pDoxorubicin[123, 124]
circBA9.3Imatinib, nilotinib, dasatinib[125]
circ_0009910miR-34a-5pImatinib[126]
Endocrine systemThyroid carcinomacircEIF6miR-144-3pCisplatin[79]
Pancreatic cancerchr14: 101402109–101464448+, chr4: 52729603–52780244+miR-145Gemcitabine[127]
26[19]
55
Cervical cancercircMTO1miR-6893Cisplatin[128]
hsa_circ_0023404miR-5047[129]
Breast cancercirc 0006528miR-7Doxorubicin[130]
ciRS-7miR-7Cisplatin, 5-FU, tamoxifen[131,132,133]
circRNA-MTO1TRAF4 proteinMonastrol[134]
hsa_circ_0025202miR-182-5pTamoxifen[135]
circBMPR2miR-553[136]
circKDM4CmiR-548pDoxorubicin[137]
Digestive systemOral carcinomahsa_circ_0005379Cetuximab[138]
Hepatocellular carcinomacircRNA_101505miR-103Cisplatin[31]
Gastric cancerhsa_circ_0000199miR-198Cisplatin[84]
hsa_circ_0081143miR-646[139]
circFN1miR-182-5p[140, 141]
circPVT1miR-124-3pPaclitaxel[141]
Colorectal cancer7735-FU and oxaliplatin[142]
732
34[29]
105
circ_001680miR-340Irinotecan[46]
ciRS-122miR-122Oxaliplatin[143]
Urinary systemRenal cancerhsa_circ_0035483miR-335Gemcitabine[144]
Bladder cancerhsa_circ_0000285[145]
ciRS-7miR-1270Cisplatin[95]
circELP3[96]
Prostate cancercircRNA17miR-181c-5pEnzalutamide[146]
588[147]
278
hsa_circ_0022392 and hsa_circ_0000326[148]
hsa_circ_0001275 and hsa_circ_0001721
Reproductive systemOvarian cancerciRS-7miR-1270Cisplatin[26]
circCELSR1miR-1252Paclitaxel[149]
MiscellaneousMyelomahsa_circ_0007841[150]
MelanomaciRS-7[151]
  1. Notes: ↑ means increased; ↓means decreased; −- means not reported yet