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Fig. 3 | Molecular Cancer

Fig. 3

From: CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17

Fig. 3

The biogenesis of circLONP2 is regulated by FUS. a Different deletion mutants for circLONP2-overexpressing plasmid. b RT-qPCR showed that only the wild type could significantly and stably overexpress circLONP2, normalized to GAPDH. c Knockdown of FUS significantly decreased the expression of circLONP2, normalized to GAPDH. d anti-FUS RIP showed significant enrichment of both I7RCM and I11RCM. e The expression of FUS and circLONP2 in CRC tissue showed significant positive correlation, normalized to GAPDH. f The mRNA level of FUS were correlated with prognosis of CRC patients in TCGA database. All experiments were repeated for three times, data were shown as mean ± SD, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001 in one-way ANOVA (b, c), Mann-Whitney U test (d), person correlation test (e) or log-rank test (f)

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