Noncoding RNAs in gastric cancer: implications for drug resistance

Table 1 MiRNAs and adriamycin resistance in gastric cancer

MiRNAs	Expression¹	Genes and Pathways	References
miR-27a	↑	P-gp, cyclin D1, p21	[54]
miR-135a-5p	↑	AP-2α	[55]
miR-BART20-5p	↑	Bad	[56]
miR-19a/b	↑	PTEN	[57]
miR-501	↑	BLID	[58, 59]
miR-20a	↑	EGR2	[60]
miR-21-5p	↑	PTEN,TIMP3	[61]
miR-633	↑	FADD	[62]
miR-520h	↑	HDAC1	[63]
miR-129-5p	↓	ABCB1, ABCC5, ABCG1	[64]
miR-508-5p	↓	ABCB1, ZNRD1	[65]
miR-103/107	↓	cav-1, P-gp	[66]
miR-27b, miR-508-5p	↓	ABCB1, CCNG1, ZNRD1	[67]
miR-140	↓	ABCC1, ABCG2, SOX4	[68]
miR-107	↓	P-gp, cyclin D1, c-myc	[69]
miR-15b, miR-16	↓	Bcl-2	[70]
miR-181b	↓	Bcl-2	[71]
miR-497	↓	Bcl-2	[72]
miR-200bc/429	↓	Bcl-2, XIAP	[73]
miR-34	↓	Bcl-2, Notch, HMGA2	[74]
miR-200c	↓	E-cadherin, Bax, Bcl-2	[75]
miR-185	↓	ARC	[76]
miR-126	↓	EZH2	[77]
miR-218	↓	SMO	[78]
miR-494	↓	PDE4D	[79]

¹miRNAs either up-regulated (↑) or down-regulated (↓) in adriamycin resistant gastric cancer cells
Note: This table shows 25 miRNAs whose expression levels and potential targets in adriamycin resistance of gastric cancer.

ISSN: 1476-4598