From: Noncoding RNAs in gastric cancer: implications for drug resistance
MiRNAs | Expression1 | Genes and Pathways | Drugs | Reference |
---|---|---|---|---|
miR-20a | ↑ | EGR2 | cisplatin | [60] |
CYLD | [83] | |||
miR-106a | ↑ | PTEN/Akt | cisplatin | [84] |
RUNX | Â | [85] | ||
miR-21 | ↑ | PTEN/Akt | cisplatin | [86] |
miR-25 | ↑ | FOXO3a | cisplatin | [87] |
miR-141 | ↑ | KEAP1 | cisplatin | [88] |
miR-223 | ↑ | FBXW7 | cisplatin | [89] |
miR-99a, miR-491 | ↑ | CAPNS1 | cisplatin | [90] |
miR-421 | ↑ | E-cadherin, caspase-3 | cisplatin | [91] |
miR-135b-5p | ↑ | KLF4 | cisplatin | [92] |
miR-135b | ↑ | MST1, MAPK | cisplatin | [93] |
miR-17-5p | ↑ | p21 | cisplatin | [94] |
miR-193a-3p | ↑ | SRSF2 | cisplatin | [28] |
miR-4295 | ↑ | LRIG1 | cisplatin | [95] |
miR-3174 | ↑ | ARHGAP10 | cisplatin | [96] |
miR-27a | ↑ | P-gp, LRP, Bcl-2 | oxaliplatin | [97] |
miR-135a | ↑ | E2F1, DAPK2 | oxaliplatin | [98] |
miR-27b, miR-508-5p | ↓ | ABCB1, CCNG1, ZNRD1 | cisplatin | [67] |
miR-129-5p | ↓ | ABCB1, ABCC5, ABCG1 | cisplatin | [64] |
miR-508-5p | ↓ | ABCB1, ZNRD1 | cisplatin | [65] |
miR-129 | ↓ | P-gp | cisplatin | [99] |
miR-107 | ↓ | P-gp, cyclin D1, c-myc | oxaliplatin | [69] |
miR-15b, miR-16 | ↓ | Bcl-2 | cisplatin | [70] |
miR-181b | ↓ | Bcl-2 | cisplatin | [71] |
miR-497 | ↓ | Bcl-2 | cisplatin | [72] |
miR-200bc/429 cluster | ↓ | Bcl-2, XIAP | cisplatin | [73] |
miR-34 | ↓ | Bcl-2, Notch, HMGA2 | cisplatin | [74] |
miR-449a | ↓ | Bcl-2, CCDN1 | cisplatin | [100] |
miR-1271 | ↓ | IGF1R, IRS1, mTOR, Bcl-2 | cisplatin | [101] |
miR-143 | ↓ | IGF1R, Bcl-2 | cisplatin | [102] |
miR-503 | ↓ | IGF1R, Bcl-2 | cisplatin | [103] |
miR-23b-3p | ↓ | ATG12, HMGB2 | cisplatin | [104] |
miR-181a | ↓ | ATG5 | cisplatin | [105] |
miR-30 | ↓ | LC3-II | cisplatin | [106] |
miR-148a-3p | ↓ | RAB12, mTOR1, AKAP1 | cisplatin | [107] |
miR-200c | ↓ | E-cadherin | cisplatin | [75] |
RhoE | [108] | |||
ZEB2 | [109] | |||
miR-101 | ↓ | ANXA2 | cisplatin | [110] |
VEGF-C | [111] | |||
miR-218 | ↓ | mTOR | cisplatin | [112] |
SMO | oxaliplatin | [78] | ||
miR-185 | ↓ | ARC | cisplatin | [76] |
miR-34a | ↓ | MET | cisplatin | [113] |
miR-26a | ↓ | NRAS, E2F2 | cisplatin | [114] |
miR-149 | ↓ | FoxM1 | cisplatin | [115] |
miR-524-5p | ↓ | SOX9 | cisplatin | [116] |
miR-362-5p | ↓ | SUZ12 | cisplatin | [117] |
miR-198 | ↓ | FGFR1 | cisplatin | [118] |
miR-574-3p | ↓ | ZEB1 | cisplatin | [119] |
miR-876-3p | ↓ | TMED3 | cisplatin | [120] |
miR-874 | ↓ | ATG16L1 | cisplatin | [121] |
let-7b | ↓ | AURKB | cisplatin | [122] |
miR-122 | ↓ | ERCC1 | cisplatin | [123] |
miR-138-5p | ↓ | ERCC1, ERCC4 | cisplatin | [48] |
miR-192-5p | ↓ | ERCC3, ERCC4 | cisplatin | [124] |