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Table 2 MiRNAs and platinum drugs resistance in gastric cancer

From: Noncoding RNAs in gastric cancer: implications for drug resistance

MiRNAs

Expression1

Genes and Pathways

Drugs

Reference

miR-20a

↑

EGR2

cisplatin

[60]

CYLD

[83]

miR-106a

↑

PTEN/Akt

cisplatin

[84]

RUNX

 

[85]

miR-21

↑

PTEN/Akt

cisplatin

[86]

miR-25

↑

FOXO3a

cisplatin

[87]

miR-141

↑

KEAP1

cisplatin

[88]

miR-223

↑

FBXW7

cisplatin

[89]

miR-99a, miR-491

↑

CAPNS1

cisplatin

[90]

miR-421

↑

E-cadherin, caspase-3

cisplatin

[91]

miR-135b-5p

↑

KLF4

cisplatin

[92]

miR-135b

↑

MST1, MAPK

cisplatin

[93]

miR-17-5p

↑

p21

cisplatin

[94]

miR-193a-3p

↑

SRSF2

cisplatin

[28]

miR-4295

↑

LRIG1

cisplatin

[95]

miR-3174

↑

ARHGAP10

cisplatin

[96]

miR-27a

↑

P-gp, LRP, Bcl-2

oxaliplatin

[97]

miR-135a

↑

E2F1, DAPK2

oxaliplatin

[98]

miR-27b, miR-508-5p

↓

ABCB1, CCNG1, ZNRD1

cisplatin

[67]

miR-129-5p

↓

ABCB1, ABCC5, ABCG1

cisplatin

[64]

miR-508-5p

↓

ABCB1, ZNRD1

cisplatin

[65]

miR-129

↓

P-gp

cisplatin

[99]

miR-107

↓

P-gp, cyclin D1, c-myc

oxaliplatin

[69]

miR-15b, miR-16

↓

Bcl-2

cisplatin

[70]

miR-181b

↓

Bcl-2

cisplatin

[71]

miR-497

↓

Bcl-2

cisplatin

[72]

miR-200bc/429 cluster

↓

Bcl-2, XIAP

cisplatin

[73]

miR-34

↓

Bcl-2, Notch, HMGA2

cisplatin

[74]

miR-449a

↓

Bcl-2, CCDN1

cisplatin

[100]

miR-1271

↓

IGF1R, IRS1, mTOR, Bcl-2

cisplatin

[101]

miR-143

↓

IGF1R, Bcl-2

cisplatin

[102]

miR-503

↓

IGF1R, Bcl-2

cisplatin

[103]

miR-23b-3p

↓

ATG12, HMGB2

cisplatin

[104]

miR-181a

↓

ATG5

cisplatin

[105]

miR-30

↓

LC3-II

cisplatin

[106]

miR-148a-3p

↓

RAB12, mTOR1, AKAP1

cisplatin

[107]

miR-200c

↓

E-cadherin

cisplatin

[75]

RhoE

[108]

ZEB2

[109]

miR-101

↓

ANXA2

cisplatin

[110]

VEGF-C

[111]

miR-218

↓

mTOR

cisplatin

[112]

SMO

oxaliplatin

[78]

miR-185

↓

ARC

cisplatin

[76]

miR-34a

↓

MET

cisplatin

[113]

miR-26a

↓

NRAS, E2F2

cisplatin

[114]

miR-149

↓

FoxM1

cisplatin

[115]

miR-524-5p

↓

SOX9

cisplatin

[116]

miR-362-5p

↓

SUZ12

cisplatin

[117]

miR-198

↓

FGFR1

cisplatin

[118]

miR-574-3p

↓

ZEB1

cisplatin

[119]

miR-876-3p

↓

TMED3

cisplatin

[120]

miR-874

↓

ATG16L1

cisplatin

[121]

let-7b

↓

AURKB

cisplatin

[122]

miR-122

↓

ERCC1

cisplatin

[123]

miR-138-5p

↓

ERCC1, ERCC4

cisplatin

[48]

miR-192-5p

↓

ERCC3, ERCC4

cisplatin

[124]

  1. 1miRNAs either up-regulated (↑) or down-regulated (↓) in platinum drugs resistant gastric cancer cells
  2. Note: This table shows 53 miRNAs whose expression levels and potential targets in platinum drugs resistance of gastric cancer.