Noncoding RNAs in gastric cancer: implications for drug resistance

Table 3 MiRNAs and 5-FU resistance in gastric cancer

MiRNAs	Expression¹	Genes and Pathways	Reference
miR-BART20-5p	↑	BAD	[56]
miR-193-3p	↑	PTEN	[127]
miR-147	↑	PTEN	[128]
miR-17	↑	DEDD	[129]
miR-129-5p	↓	ABCB1, ABCC5, ABCG1	[64]
miR-508-5p	↓	ABCB1, ZNRD1	[65]
miR-27b, miR-508-5p	↓	ABCB1, CCNG1, ZNRD1	[67]
miR-107	↓	P-gp, cyclin D1, c-myc,	[69]
miR-181b	↓	Bcl-2	[71]
miR-429	↓	Bcl-2	[130]
miR-200c	↓	E-cadherin	[75]
miR-218	↓	SMO	[78]
miR-23b-3p	↓	ATG12, HMGB2	[104]
miR-31	↓	RhoA	[131]
		ZH2	[132]
		E2F6, SMUG1	[133]
miR-197	↓	MAPK1	[134]
miR-BART15-3p	↓	TAX1BP1	[135]
miR-195-5p	↓	ZNF139	[136]
miR-204	↓	TGFBR2	[137]
miR-623	↓	CCND1	[138]
miR-939	↓	SLC34A2/Raf/MEK/ERK	[139]
miR-124	↓	EZH2	[140]

¹ miRNAs either up-regulated (↑) or down-regulated (↓) in 5-FU resistant gastric cancer cells
Note: This table shows 21 miRNAs whose expression levels and potential targets in 5-FU resistance of gastric cancer.

ISSN: 1476-4598