Noncoding RNAs in gastric cancer: implications for drug resistance

Table 6 MiRNAs and targeted therapy drugs resistance in gastric cancer

MiRNAs	Expression¹	Genes and Pathways	Drugs	Reference
miR-21	↑	PTEN	trastuzumab	[154]
miR-125b	↑		trastuzumab	[155]
miR-223	↑	FBXW7	trastuzumab	[156]
miR-200c	↓	ZEB1, ZEB2	trastuzumab	[157]
miR-16	↓	CCNJ, FUBP1	trastuzumab, lapatinib	[158]
miR-494	↓	FGFR2	lapatinib	[159]

¹ miRNAs either up-regulated (↑) or down-regulated (↓) in targeted drugs resistant gastric cancer cells
Note: This table shows 6 miRNAs whose expression levels and potential targets in targeted therapy drugs resistance of gastric cancer.

ISSN: 1476-4598