Fig. 3
From: microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation
Regulation of cell cycle progression by miRNAs in prostate cancer radiation response. Following DNA damage induced by irradiation, cell cycle arrest is initiated in order to allow DNA damage repair. Cell cycle progression depends on cyclin dependent kinases (CDKs), cyclins, inhibitors and also transcription factors family E2F, themselves regulated by miRNAs, whose expression could be modulated by irradiation. S, S-phase; M, Mitosis; G1 and G2 indicate transition phases of the cell cycle; G0 indicates quiescent cells; PTEN, Phosphatase and TENsin homolog; CDC25A, Cell division cycle 25 A; Rb, Retinoblastoma protein; AKT, protein kinase B; P, phosphorylation; SGGP1, sphingosine-1-phosphate phosphatase 1