Fig. 4
From: microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation
Overview of several actors in the tumor microenvironment modulated by miRNAs involved in irradiation response. Irradiation-modulated miRNAs regulate tumor microenvironment (TME), affecting the radiation response. Angiogenesis, hypoxia, epithelial to mesenchymal transition (EMT) and the immune system are notably affected. Green arrow indicates an induction of the TME actors. Red inhibiting line indicates an inhibition of the TME actors. Up- or down- arrows, next to miRNAs, indicate the expression of miRNAs after irradiation. For miRNAs where no arrow is indicated, means that the miRNA influences the radiation response by modulating TME actors but its up- or down-regulation in PCa cells following irradiation has not been studied. T cells, Lymphocytes T; PD-1, Programmed death 1; PD-L1, Programmed death-ligand 1