Table 1 miRNAs dysregulated by irradiation in prostate cancer cells

Increased

let-7e, miR-18b miR-92a-1, miR-92a-2, miR-320a, miR-365-1, miR-365-2

PC-3-RR cells

2 Gy x 45, fractionnated

NGS

[40]

-

miR-95

Radioresistance [40]

miR-9, miR-22, miR-25, miR-550a, miR-548h

PC-3 cells

10 Gy

NGS

[41]

-

miR-30a

Radiosensitization [42]

let-7 family, miR-34a, miR-146a

PC-3 and LNCaP cells

0.5 Gy x10, 1 Gy x10, fractionned

microarray

[43]

-

miR-16

LNCaP cells

0.5 or 4 Gy

microarray

[44]

Radiosenzitization [45]

miR-34c, miR-372, miR-520c, miR-520f

LNCaP cells

6 Gy

microarray

[46]

-

miR-449

Radiosensitization [47, 48]

miR-9-1, miR-22, miR-24, miR-29b, miR-141, miR-191, miR-200c

LNCaP cells

6 Gy

microarray

[49]

-

miR-30a

Radiosensitization [42]

51 miRNAs increased notably miR-29a, miR-130a, miR-4521

22RV1-RR compared to 22RV1 cells

60 Gy, (2 Gy fractioned doses)

microarray

[50]

-

miR-221, miR-222

Radioresistance [51]

miR-34c, miR-154*, miR-379, miR-383, miR-488

C4-2 cells

6 Gy

microarray

[46]

-

Decreased

let-7c, let-7d, let-7e , miR-15a, miR-30d, miR-92a, miR-125a, miR-197, miR-221, miR-320b, miR-342, miR-361, miR-374a, miR-501, miR-671

PC-3 cells

10 Gy

NGS

[41]

miR-17

Radiosensitization [52]

miR-17-92 cluster

PC-3, LNCaP and DU145 cells

5 and 10 Gy, single dose and 0.5 Gy x 10, 1 Gy x 10 fractionned dose

microarray

[43]

-

miR-100

LNCaP cells

6 Gy

microarray

[46]

Radiosensitization [53]

miR-107, miR-122a, miR-133b, miR-187, miR-196a, miR-487

-

miR-145

Radiosensitization [54]

miR-521

Radiosensitization [55]

miR-106b

LNCaP cells

6 Gy

microarray

[49]

Radioresistance [55]

miR-199a

-

miR-133b, miR-135b, miR-143, miR-196a, miR-218, miR-521

C4-2 cells

6 Gy

microarray

[46]

-

46 miRNAs decreased notably miR-141, miR-3607, miR-4284

22RV1-RR compared to 22RV1 cells

60 Gy (2 Gy fractioned doses)

microarray

[50]

-