Hematological malignancy | PVT1 | Molecular alteration | Downstream genes (direct or indirect regulation) | Functional role | References |
---|---|---|---|---|---|
AML | Linear | Genomic amplification, rearrangements (PVT1-CCDC26 PVT1-NSMCE2), upregulation | MYC | ↑ proliferation, ↓ apoptosis, maintenance of an undifferentiated phenotype | |
AML | Circular | Genomic amplification, rearrangements | [41] | ||
APL | Linear | Genomic amplification, upregulation | MYC | Maintenance of an undifferentiated phenotype, cell cycle progression | |
AEL | Linear | Upregulation | MYC, p15, p16, BCL2 | ↑ proliferation, ↓ apoptosis and necrosis | |
B-ALL | Circular | Upregulation | MYC, BCL2 | ↑ proliferation, ↓ apoptosis | |
T-ALL | Circular | Upregulation | MYC, BCL2 | ↑ proliferation, ↓ apoptosis | [50] |
T-ALL | Linear | Upregulation | MYC, p15, p16, BCL2, Caspase-3 | ↑ proliferation, ↓ apoptosis | [52] |
CLL | Linear | t(8;13) (q24;q14) and deletion, upregulation | [53] | ||
BL | Linear | t(2;8), t(8;22) | MYC, CDKN2A, CDN1B, RB1, CCND2, GADD45A, CDC20, CDK4, CD6, ATM, BRCA2 | ↑ proliferation | |
HL | Susceptibility loci at 8q24.21 near or in the PVT1 gene | rs2019960, rs2608053 | |||
DLBCL | Susceptibility loci at 8q24.21 in close proximity to PVT1, focal promoter deletions, amplification | rs13255292, and rs4733601 | MYC, BCL2 | double-hit-like expression pattern (focal deletions of promoter) | |
FL | Susceptibility locus at 8q24.21 near PVT1 | rs13254990 | [65] | ||
MM | Linear | Genomic amplification, translocations, upregulation | MYC, BCL2, miR-203 | ↑ proliferation, ↓ apoptosis | |
MM | Circular | Upregulation | BCL2, Caspase-3, PARP | ↑ proliferation, ↓ apoptosis, resistance to glucocorticoid treatment | [70] |