From: The role of long noncoding RNAs in hepatocellular carcinoma
LncRNAs | Roles in HCC | Binding partners | Action modes | Outcomes | Refs |
---|---|---|---|---|---|
Dreh | Tumor suppressor | Vimentin protein | Cytoskeleton reorganization | ↓ metastasis ↓ proliferation | [24] |
ATB | Oncogene | miR-200 | miRNA sponge | ↑ metastasis | [40] |
UFC1 | Oncogene | β-catenin mRNA HuR protein | mRNA stabilization | ↑ proliferation | [54] |
PXN-AS1 | Oncogene | PXN mRNA | mRNA stabilization | ↑ proliferation | [55] |
ANRIL | Oncogene | EZH2 protein Target gene DNA | Transcriptional suppression | ↑ proliferation | [56] |
TUG1 | Oncogene | EZH2 protein Target gene DNA | Transcriptional suppression | ↑ proliferation ↑ glycolysis | |
lnc-β-Catm | Oncogene | EZH2 protein β-catenin protein | Protein stabilization | ↑ stemness | [59] |
GIHCG | Oncogene | EZH2 protein Target gene DNA | Transcriptional suppression | ↑ proliferation ↑ metastasis | [60] |
DANCR | Oncogene | β-catenin mRNA | mRNA stabilization | ↑ stemness | [61] |
MALAT1 | Oncogene | miR-143-3p | miRNA sponge | ↑ metastasis ↑ proliferation | [62] |
HULC | Oncogene | miR-186 miR-9 | miRNA sponge | ↑ proliferation ↑ lipogenesis | |
XIST | Tumor suppressor | miR-92b | miRNA sponge | ↓ metastasis ↓ proliferation | [65] |
PVT1 | Oncogene | NOP2 protein | Protein stabilization | ↑ stemness | [66] |
HOTTIP | Oncogene | miR-192 miR-204 | miRNA sponge | ↑ glutaminolysis | [67] |
DILC | Tumor suppressor | IL-6 DNA | Transcriptional suppression | ↓ stemness | [68] |
ICR | Oncogene | ICAM-1 mRNA | mRNA stabilization | ↑ stemness | [69] |
ZFAS1 | Oncogene | miR-150 | miRNA sponge | ↑ metastasis | [70] |
MVIH | Oncogene | PGK1 protein | Protein localization | ↑ metastasis | [71] |
CASC9 | Oncogene | HNRNPL protein | Protein phosphorylation | ↑ proliferation | [72] |