Fig. 1

Analyses of the CD151-derived circRNA expression and prognosis in melanoma. a The heatmap shows the CD151-derived circRNA expression of four melanoma and non-tumor tissues analyzed by qRT-PCR. b Schematic illustration demonstrates circ_0020710 formation via exons 1–9 circularization of the CD151 gene. The presence of circ_0020710 was validated by qRT-PCR, followed by Sanger sequencing. c and d The relative expression of circ_0020710 in 88 paired melanoma and normal tissues and 18 benign nevi tissues was analyzed by qRT-PCR. Paired student’s t-test and Mann-Whitney U test were used for the statistical analyses. e The AUC of the ROC curve in distinguishing melanoma and normal tissues. f Based on the expression of circ_0020710, the overall survival curve was performed using Kaplan-Meier methods and analyzed by the log-rank test. g Multivariate analyses of factors associated with OS. *p < 0.05; **p < 0.01