Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation

Table 1 Writers, readers and erasers of the predominant mRNA modifications

RNA modification	Writers	Readers	Erasers
m⁶A	METTL3; METTL14; WTAP; RBM15; ZC3H13	YTH domain family of proteins (YTHDF1, YTHDF2, YTHDF3, YTHDC1 and YTHDC2); HNRNP (HNRNPA2B1 and HNRNPC); eIF3; IGF2BP (IGF2BP1, IGF2BP2, and IGF2BP3); FMR1; LRPPRC	FTO; ALKBH5
m¹A	TRMT6/61A; TRMT61B; TRMT10C	YTHDF1; YTHDF2; YTHDF3; YTHDC1	ALKBH1; ALKBH3
m⁵C	NSUN2; DNMT2	ALYREF; YBX1	N.A.

ISSN: 1476-4598