From: Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis
Biological functions | seRNA’s name | Locations | Effects on cancer development | Mechanisms | Ref |
---|---|---|---|---|---|
EMT | HCCL5 | HCC | Exacerbate | Up-regulating Snail, Slug, ZEB1 and Twist1 expression. | [72] |
CCAT1-L | Bladder, cervical and ovarian cancer | Exacerbate | Promoting invasion and metastasis. | ||
circRNA | HCC | Exacerbate | YY1/p65/p300 complex promotes circRNA transcription. | [76] | |
Apoptosis | UCA1 | NB and GC | Alleviate | Enhancing AMOTp130-YAP and Hippo-YAP activity. | |
Autophagy | UCA1 | Breast carcinoma | Exacerbate | UCA1-induced Hippo-YAP activity suppresses autophagy. | |
LINC01503 | SCC | Exacerbate | Accelerating autophagy via activating PI3K/AKT and ERK/p38 MAPK signaling. | ||
Angiogenesis | circNfix | ATC and RCC | Exacerbate | Activating GSK3β-mediated β-catenin, ANG and AM signaling and up-regulating VEGF. | |
UCA1 | PDAC | Exacerbate | Enhancing Hippo-YAP activity and YAP-TEAD interaction. | [84] | |
Immune response | seRNA | CD4+ T and Treg cells | Alleviate | Regulating the T and Treg cells differentiation, maturation. | |
seRNA | B cells | Alleviate | Enhancing B cells activation and humoral immunity. | ||
seRNA | Macrophages | Alleviate | Driving immunity and enhancing the release of IFN-γ. | [90] | |
seRNA | IFN-γ | Alleviate | Enhancing function of CD4+ T and NK cells. | [91] | |
CCAT1 | PD-L1 | Exacerbate | Up-regulating PD-L1 by activating PI3K/AKT and RAF/MEK/ERK signaling. | [92] | |
CCAT1 | PD-L1, CD47 | Exacerbate | Up-regulating PD-L1 and CD47 by inducing MYC. | [93] | |
ECM | UCA1 | GC, CRC, lung and breast cancer | Exacerbate | Up-regulating α–SMA and ECM proteins. | |
seRNA | Brest cancers | Exacerbate | Driving CAFs proliferation and myofibroblast differentiation. | ||
Oncogene expression | MYC- seRNA | LCLs | Exacerbate | Promoting transcriptional activation of MYC oncogene. | [5] |
CCAT1-L | CRC | Exacerbate | Assembling CTCF and up-regulating MYC. | [32] | |
Cancer cells proliferation | CCAT1 | SCC | Exacerbate | Forming CCAT1/TP63/SOX2 complex to activate EGFR-induced RAF/MEK/ERK and PI3K/AKT signaling. | [24] |
TP53- seRNA | Various cancers | Alleviate | Increasing TP53 transcription and inducing cell-cycle arrest. | [99] |