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Fig. 5 | Molecular Cancer

Fig. 5

From: Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis

Fig. 5

MiR-34b-5p inhibits the proliferation, migration, and invasion of PDAC cells. a, b qRT-PCR analysis of the relative expression levels of miR-34b-5p in pancreatic epithelial cells (hTERT-HPNE), PDAC cells (BxPC-3, MIA PaCa-2, CFPAC-1, and PANC-1) (a), and tissues (b). The nonparametric Mann-Whitney U-test was used. c The expression levels of miR-34b-5p in patients with PDAC with different pathological stages. d-i After transfection with miR-34b-5p mimics or inhibitor in PANC-1 and BxPC-3 cells, a colony formation assay was used to evaluate the colony formation ability of the cells. j-m Representative images of Transwell migration and Matrigel invasion assays showing the effect of migratory and invasive of PANC-1 and BxPC-3 cells transfected with miR-34b-5p mimics or inhibitors. The images were photographed at 100X magnification. Scale bar =100 μm. Statistical significance was assessed using two-tailed t-tests for two group comparison, and one-way ANOVA followed by Dunnett’s tests for multiple comparison. The error bars represent the standard deviations of three independent experiments. *P < 0.05, **P < 0.01

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