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Fig. 1 | Molecular Cancer

Fig. 1

From: Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Fig. 1

Aberrant epigenetic alterations in tumour development. Within tumour cells, the activated epigenetic modifiers switch on the transcription of oncogenes and onco-miRNAs, assisting the formation of cancer hallmarks. However, the suppressive epigenetic modifiers switch off the transcription of TSGs and tumour-suppressive miRNAs, which exert inhibitory effects on tumorigenesis. The TME is subject to epigenetic modifications and assists in creating a pre-metastatic and immune suppressive niche for tumour cells

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Molecular Cancer

ISSN: 1476-4598