Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

Table 1 Effect of ASK120067 on cancer cells harboring mutant or wild-type EGFR

ASK120067 inhibited the proliferation of cell lines harboring the T790M mutation (NCI-H1975 cells) or sensitizing mutations (PC-9 and HCC-827 cells), while it exhibited less potency against cell lines harboring EGFR ^WT (A431, LoVo and A549 cells). IC₅₀ values are shown as the mean ± SD from three independent experiments

ISSN: 1476-4598