Fig. 4

MiR-6792-3p is highly expressed in gastric cancer tissues and correlated with the progression and poor prognosis. a. Schematic illustration exhibiting overlapping of the target miRNAs of circCCDC9 predicted by circNET, RNAhybrid and miRanda. b and c. Relative expression of candidate miRNAs in MKN-45 cells (b) and AGS cells (c). d and e. Relative expression of miR-6792-3p in GC tissues and matched adjacent normal tissues was detected by qRT-PCR (n = 48). f. Relative expression of miR-6792-3p in GC cell lines and normal cell line was detected by qRT-PCR. g. Kaplan-Meier plots of the overall survival of GC patients with high and low levels of miR-6792-3p. The cut-off point came from the median value. h. Represent images of miR-6792-3p expression in GC tissues with GTD < 5 cm, GTD ≥5 cm, stage II, stage III, N0, N1, N2, N3 and paired adjacent normal tissues. i. The level of miR-6792-3p in GC tissues was significantly higher than in paired adjacent normal tissues. j-l. The level of miR-6792-3p in GC tissues with GTD ≥5 cm (J), stage III (K) N1, N2 and N3 (L), was significantly higher than those with GTD < 5 cm, stage II and N0, respectively. m and n. Kaplan-Meier survival analysis (log-rank test) showed that gastric cancer patients with high miR-6792-3p expression had lower OS and DFS than those with low miR-6792-3p expression. The white scale bar indicated 20 μm. Data were showed as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001