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Fig. 8 | Molecular Cancer

Fig. 8

From: Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression

Fig. 8

Overexpression of circCCDC9 inhibits the growth of gastric cancer in vivo. a. Image of subcutaneous tumor tissues in circCCDC9-overexpressing group and control group. b. The relative weights of tumors were evaluated. c. Analysis of tumor volume of mice measured every week. d. Relative expression levels of circCCDC9, miR-6792-3p and CAV1 were observed in subcutaneous tumor tissues by qRT-PCR. e. Relative expression levels of CAV1, β-catenin, cyclin D1 and E-cadherin were observed in subcutaneous tumor tissues by western blot assays. f. Relative expression levels of CAV1, β-catenin, cyclin D1 and E-cadherin were observed in subcutaneous tumor tissues by IHC. g. Representative images in HE staining of the liver metastasis of AGS cells. h. The schematic diagram shows the mechanism underlying circCCDC9 as a ceRNA for miR-6792-3p to regulate CAV1 expression in the progression of gastric cancer. Data were showed as mean ± SD. *P < 0.05, **P < 0.01

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