From: Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer
Molecule | Mechanism | ncRNA | Biological function | Ref. |
---|---|---|---|---|
Writers | ||||
METTL3 | Promote pri-miRNA processing | miR-221/222 | Promote cell proliferation in bladder cancer | [35] |
Promote pri-miRNA processing | miR-1246 | Promote cell migration in CRC | [36] | |
Promote pre-miRNA processing | miR-143-3p | Promote the brain metastasis of NSCLC | [37] | |
Promote pri-miRNA processing | miR-25 | Promote cell proliferation in pancreatic cancer | [41] | |
Modulate the structure of lncRNA | MALAT1 | Promote cell proliferation | [13] | |
Stabilize lncRNA and enable the ceRNA model | LINC00958 | Promote HCC lipogenesis and progression. | [60] | |
Stabilize lncRNA and enable the ceRNA model | MALAT1 | Promote NSCLC drug resistance and metastasis | [61] | |
Promote lincRNA-let-7 interaction | Linc1281 | Regulate pluripotency and differentiation of mESC | [62] | |
METTL14 | Promote pri-miRNA processing | miR-126 | Suppress HCC metastasis | [17] |
Promote pri-miRNA processing | miR-375 | Suppress CRC progression | [38] | |
Modulate the structure of lncRNA | MALAT1 | Promote cell proliferation | [13] | |
WTAP, RBM15, RBM15B | Promote XIST -mediated gene repression | XIST | Gene silencing on the X chromosome | |
NSun2 | Suppress pri-miRNA processing | miR-125b | Promote cell migration in CRC | [44] |
METTL16 | Regulate pre-mRNA splicing | U6 snRNA | Â | [24] |
ZCCHC4 | Promote mRNA translation | 28S rRNA | Promote cell proliferation | [26] |
Erasers | ||||
FTO | Affect steady-state levels of several miRNAs | miRNAs | Â | [43] |
Suppress cap-independent translation | circRNAs | Â | [14] | |
Readers | ||||
NKAP | Promote pri-miRNA processing | miR-25 | Promote cell proliferation in pancreatic cancer | [41] |
HNRNPA2B1 | Promote pri-miRNA processing | miR-106b | Promote NSCLC cell proliferation and tumor growth | [40] |
 | Alter miRNAs transcriptome | miR-29a-3p, miR-29b-3p, miR-222, miR-1266-5p, miR-1268a, miR-671-3p | Promote endocrine resistance in breast cancer | [45] |
HNRNPC | Promote pri-miRNA processing | miR-21 | Promote cell migration and invasion in glioblastoma | [42] |
HNRNPC, HNRNPG | Regulate RNA abundance and alternative splicing pattern | MALAT1 | Promote cell proliferation | |
YTHDC1 | Promote XIST -mediated gene repression | XIST | Gene silencing on the X chromosome | [20] |
 | Promote cytoplasmic export of circRNAs | circNSun2 | Promote cell invasion and liver metastasis in CRC | [69] |
YTHDF2 | Mediate circRNA degradation | circRNAs | Inhibit innate immunity | |
YTHDF3 | Drive cap-independent translation | circRNAs | Â | [14] |