Fig. 2
From: Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection
Comparative meta-analysis of the tissue-specific differential expression of the ACE2 and TMPRSS2 genes in lung tissues performed by LCE. a ACE2 in normal lung tissue and lung cancer tissue samples from TCGA_LUAD_2016 (p-val = 6.4e− 06); b ACE2 in normal lung tissue and lung cancer tissue samples from TCGA_LUSC_2016 (p-val = 0.11); c TMPRSS2 in normal lung tissue and lung cancer tissue samples from TCGA_LUAD_2016 (p-val = 3e− 31); d TMPRSS2 in normal lung tissue and lung cancer tissue samples from TCGA_LUSC_2016 (p-val = 4.1e− 81); e Meta-analysis of ACE2 expression in LUAD tissue vs. normal lung tissue(p-val = 3.8e− 05, I2 = 62%); f Meta-analysis of ACE2 expression in LUSC tissue vs. normal lung tissue (p-val = 0.0011, I2 = 47%); g Meta-analysis of TMPRSS2 expression in LUAD tissue vs. normal lung tissue (p-val = 0.072, I2 = 86%); h Meta-analysis of TMPRSS2 expression in LUSC tissue vs. normal lung tissue (p-val = 1.3e− 12, I2 = 88%); i ACE2 genes expression in human airway bronchial epithelial cells (Calu-3, a non-small-cell lung cancer cell line) infected with SARS-CoV; and j. TMPRSS2 genes expression in human airway bronchial epithelial cells (Calu-3, a non-small-cell lung cancer cell line) infected with SARS-CoV; k ACE2 protein expression among lung tissue, LUAD, and LUSC with data from HPA; l TMPRSS2 protein expression among lung tissue, LUAD, and LUSC with data from HPA