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Table 2 Univariate and multivariate analyses of factors associated with survival and recurrence

From: Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

Factors

OS

Cumulative recurrence

Univariate, P

multivariate

Univariate, P

multivariate

HR

95% CI

p value

HR

95% CI

p value

Age (years) (< 52 vs. ≥52)

0.888

  

NA

0.469

  

NA

Sex (female vs. male)

0.060

  

NA

0.127

  

NA

HBsAg (positive vs. negative)

0.183

  

NA

0.622

  

NA

Liver cirrhosis (yes vs. no)

0.930

  

NA

0.127

  

NA

Tumor size (diameter, cm) (> 5 vs. ≤ 5)

0.001

1.728

1.148–2.600

0.009

< 0.001

1.729

1.194–2.502

0.004

Tumor encapsulation (absent vs. present)

0.195

  

NA

0.043

  

NS

microvascular invasion (yes vs. no)

< 0.001

2.365

1.536–3.640

< 0.001

< 0.001

1.664

1.119–2.476

0.012

Tumor number (multiple vs. single)

0.045

1.213

0.735–2.002

NS

0.002

1.587

1.005–2.507

0.048

HCC staging

0.002

  

NA

< 0.001

  

NA

CircMET expression (high vs. low)

0.007

1.522

1.010–2.294

0.045

0.004

1.480

1.023–2.142

0.037

  1. Abbreviations and Note: OS overall survival, NA not adopted, NS not significant, HBsAg hepatitis B surface antigen, 95%CI 95% confidence interval, HR Hazard ratio, Cox proportional hazards regression model