Factors | OS | Cumulative recurrence | ||||||
---|---|---|---|---|---|---|---|---|
Univariate, P | multivariate | Univariate, P | multivariate | |||||
HR | 95% CI | p value | HR | 95% CI | p value | |||
Age (years) (< 52 vs. ≥52) | 0.888 |  |  | NA | 0.469 |  |  | NA |
Sex (female vs. male) | 0.060 | Â | Â | NA | 0.127 | Â | Â | NA |
HBsAg (positive vs. negative) | 0.183 | Â | Â | NA | 0.622 | Â | Â | NA |
Liver cirrhosis (yes vs. no) | 0.930 | Â | Â | NA | 0.127 | Â | Â | NA |
Tumor size (diameter, cm) (> 5 vs. ≤ 5) | 0.001 | 1.728 | 1.148–2.600 | 0.009 | < 0.001 | 1.729 | 1.194–2.502 | 0.004 |
Tumor encapsulation (absent vs. present) | 0.195 | Â | Â | NA | 0.043 | Â | Â | NS |
microvascular invasion (yes vs. no) | < 0.001 | 2.365 | 1.536–3.640 | < 0.001 | < 0.001 | 1.664 | 1.119–2.476 | 0.012 |
Tumor number (multiple vs. single) | 0.045 | 1.213 | 0.735–2.002 | NS | 0.002 | 1.587 | 1.005–2.507 | 0.048 |
HCC staging | 0.002 |  |  | NA | < 0.001 |  |  | NA |
CircMET expression (high vs. low) | 0.007 | 1.522 | 1.010–2.294 | 0.045 | 0.004 | 1.480 | 1.023–2.142 | 0.037 |