Table 2 Suppressive roles of m6A proteins and biological mechanisms exerted in human tumors
From: Mechanism of RNA modification N6-methyladenosine in human cancer
Cancer | Regulator | Role in cancer | Mechanism | Functional classification | Refs |
|---|---|---|---|---|---|
GBM | METTL3 METTL14 | Suppressor | Downregulate oncogenes like ADAM19 | Suppress GSCs growth and self-renewal | [49] |
HCC | METTL14 | Suppressor | Interact with DGCR8 and modulate the primary miR-126 process | Suppress tumor invasion and metastasis | [100] |
HCC | YTHDF2 | Suppressor | Inhibit STAT3 phosphorylation by degrading IL11 and SERPINE2 mRNA; Activate MEK/ERK pathway, destabilizing EGFR mRNA | Inhibit inflammation, vascular reconstruction and metastatic progression | [101] [102] |
CRC | METTL3 | Suppressor | Regulate p38/ERK pathways | Suppress CRC cancer proliferation and migration | [103] |
CRC | METTL14 | Suppressor | Regulate primary miR-375 processing | Inhibit CRC cell growth and metastasis | [104] |
PDAC | ALKBH5 | Suppressor | Demethylate lncRNA KCNK15-AS1 | Inhibit pancreatic cancer motility and EMT | [105] |
PDAC | YTHDF2 | Suppressor | Destabilize YAP mRNA | Inhibit cancer migration, invasion, and adhesion ability | [79] |
BCA | METTL14 | Suppressor | Target Notch1 | Inhibit bladder TIC self-renewal and bladder tumorigenesis | [106] |
RCC | METTL3 | Suppressor | Change EMT and PI3K-Akt-mTOR pathways | Suppress proliferation, migration, invasion function and cell cycle of RCC | [107] |
RCC | FTO | Suppressor | Increase expression of PGC-1α | Impair tumor growth and induce apoptosis via regulating mitochondrial biogenesis and oxidative phosphorylation | [108] |
EC | METTL3/METTL14 METTL14 | Suppressor | Active AKT signaling pathway | Inhibit the proliferation and tumorigenicity of in vitro and in vivo | [109] |
Melanoma | YTHDF1 | Suppressor | Bind HINT2 | Restrain cell growth and migratory ability | [110] |