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Table 2 Suppressive roles of m6A proteins and biological mechanisms exerted in human tumors

From: Mechanism of RNA modification N6-methyladenosine in human cancer

Cancer Regulator Role in cancer Mechanism Functional classification Refs
GBM METTL3
METTL14
Suppressor Downregulate oncogenes like ADAM19 Suppress GSCs growth and self-renewal [49]
HCC METTL14 Suppressor Interact with DGCR8 and modulate the primary miR-126 process Suppress tumor invasion and metastasis [100]
HCC YTHDF2 Suppressor Inhibit STAT3 phosphorylation by degrading IL11 and SERPINE2 mRNA;
Activate MEK/ERK pathway, destabilizing EGFR mRNA
Inhibit inflammation, vascular reconstruction and metastatic progression [101]
[102]
CRC METTL3 Suppressor Regulate p38/ERK pathways Suppress CRC cancer proliferation and migration [103]
CRC METTL14 Suppressor Regulate primary miR-375 processing Inhibit CRC cell growth and metastasis [104]
PDAC ALKBH5 Suppressor Demethylate lncRNA KCNK15-AS1 Inhibit pancreatic cancer motility and EMT [105]
PDAC YTHDF2 Suppressor Destabilize YAP mRNA Inhibit cancer migration, invasion, and adhesion ability [79]
BCA METTL14 Suppressor Target Notch1 Inhibit bladder TIC self-renewal and bladder tumorigenesis [106]
RCC METTL3 Suppressor Change EMT and PI3K-Akt-mTOR pathways Suppress proliferation, migration, invasion function and cell cycle of RCC [107]
RCC FTO Suppressor Increase expression of PGC-1α Impair tumor growth and induce apoptosis via regulating mitochondrial biogenesis and oxidative phosphorylation [108]
EC METTL3/METTL14
METTL14
Suppressor Active AKT signaling pathway Inhibit the proliferation and tumorigenicity of in vitro and in vivo [109]
Melanoma YTHDF1 Suppressor Bind HINT2 Restrain cell growth and migratory ability [110]
  1. GBM glioblastoma; HCC hepatocellular carcinoma; CRC colorectal cancer; PDAC pancreatic cancer; BCA bladder cancer; RCC renal cell carcinoma; EC Endometrial cancer