Table 3 The mutations of m6A genes in several cancers
From: Mechanism of RNA modification N6-methyladenosine in human cancer
Regulators | Mutation frequency | Cancer | Role | Data source | Effect/ Mechanism on cancer | Refs |
|---|---|---|---|---|---|---|
METTL3/METTL14/YTHDF1/YTHDF2/FTO/ALKBH5 | 2.60% | AML | Oncogene | cBioPortal | Predict poorer OS and EFS independently | [142] |
all included m6A enzymes | 24% | BC | NM | cBioPortal/METABRIC | NM | [143] |
all included m6A enzymes | 23.33% | GC | Oncogene | TCGA | Predict malignant phenotypes and augmenting Wnt/PI3K-Akt signaling | [144] |
METTL14 | 1.50% | EC | Oncogene | cBioPortal | Regulate AKT activity to promote tumorigenicity | [109] |