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Table 3 The mutations of m6A genes in several cancers

From: Mechanism of RNA modification N6-methyladenosine in human cancer

Regulators Mutation
frequency
Cancer Role Data source Effect/ Mechanism on cancer Refs
METTL3/METTL14/YTHDF1/YTHDF2/FTO/ALKBH5 2.60% AML Oncogene cBioPortal Predict poorer OS and EFS independently [142]
all included m6A enzymes 24% BC NM cBioPortal/METABRIC NM [143]
all included m6A enzymes 23.33% GC Oncogene TCGA Predict malignant phenotypes and augmenting Wnt/PI3K-Akt signaling [144]
METTL14 1.50% EC Oncogene cBioPortal Regulate AKT activity to promote tumorigenicity [109]
  1. AML acute myeloid leukemia; BC breast-invasive carcinoma; GC gastric carcinoma; EC Endometrial cancer; NM not mentioned