Fig. 1

LINC00173.v1 is specifically overexpressed in lung squamous cell carcinoma. a Expression level of LINC00173 in 340 adjacent normal tissues (ANT), 1107 adenocarcinoma cell carcinoma (ADC), 399 squamous cell carcinoma (SQC) and 282 other subtypes of lung cancer, including Adenosquamous carcinoma (ASC), Large cell neuroendocrine carcinoma (LCNE), Undifferentiated carcinoma (UDC), Epidermoid carcinoma (EPC), Sarcomatoid carcinoma (SARC), Pleomorphic carcinoma (PMC), and Non-specific types of NSCLC in AE-meta. Each bar represents the median values ± quartile values. P value was determined by one-way ANOVA test. n.s. indicates no significance. b Expression level of LINC00173 in 109 ANT, 511 ADC and 502 SQC in TCGA. Each bar represents the median values ± quartile values. P value was determined by one-way ANOVA test. c Comparison of LINC00173 expression between SQC, ADC and their matched ANT in TCGA. *P < 0.05 by paired t test. d Identification of two LINC00173 transcripts and their exon sequences in UCSC genome browser. e RNA expression of LINC00173.v1 and LINC00173.v2 in ADC and SQC patient samples. *P < 0.05 by paired t test. f Comparison of LINC00173.v1 expression between ADC, SQC and matched ANT in TCGA. *P < 0.05 by paired t test. g RSEM percentages of LINC00173.v1 and LINC00173.v2 based on their reads in lung cancer dataset from TCGA. h ΔCt references of LINC00173.v1 and LINC00173.v2 in lung cancer tissues and ANT in real-time PCR analysis relative to GAPDH. *P < 0.05 by paired t test