Skip to main content
Fig. 5 | Molecular Cancer

Fig. 5

From: Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance

Fig. 5

LncRNAs regulate chemoresistance through modulating MDR-related genes. The ABC transporters export chemotherapy drugs out of the cells, leading to resistance with reduced concentrations of the drugs intracellularly. The transporters also sequestrate intracellular drugs into membrane vesicles in the cytoplasm, resulting in chemotherapy resistance. LncRNAs can act as a ceRNA, directly bind to mRNAs or proteins, and regulate MDR through up-regulating the expression of MDR-related genes (MDR1 and MRP1)

Back to article page

Molecular Cancer

ISSN: 1476-4598