LncRNA | Effection | Drugs | Pathway/target | Mechanism | Refs |
---|---|---|---|---|---|
MALAT1 | Inducing | 5-FU, DDP, VCR | miR-23B-3P, ATG12, miR-30b, ATG5, SOX2, nanog | CeRNA, Inducing autophagy, Increasing cancer stemness | |
AK022798 | Inducing | DDP | caspase8, caspase3, MRP1 | Inhibiting cell apoptosis, Regulating MDR-related genes | [124] |
CRAL | Reversing | DDP | miR-505, CYLD, PI3K/AKT | CeRNA, Promoting DNA damage and apoptosis | [125] |
ROR | Inducing | ADR, VCR | MRP1 | Inhibiting cell apoptosis, Regulating MDR-related genes | [126] |
XLOC_006753 | Inducing | 5-FU, DDP | PI3K/AKT/mTOR, caspase9, Wnt/β-catenin, Vimentin, Snail | Inhibiting cell apoptosis, Promoting EMT | [127] |
MACC1-AS1 | Inducing | 5-FU, OXA | miR-145-5p, CD133, OCT4, SOX2, LIN28 | CeRNA, Increasing cancer stemness | [128] |
D63785 | Inducing | DOX | miR-422a, MEF2D | CeRNA, Inhibiting cell apoptosis | [129] |
LINC01433 | Inducing | DOX, DDP | YAP, USP9X | Inhibiting cell apoptosis | [130] |
HOXD-AS1 | Inducing | DDP | EZH2, PDCD4, H3K27me3 | Epigenetically silencing PDCD4 via recruiting EZH2 | [131] |
HULC | Reversing | DDP, ADM, 5-FU | FOXM1 | Suppressing autophagy, Promoting cell apoptosis | |
PCAT-1 | Inducing | DDP | miR-128, ZEB1, EZH2, PTEN, H3K27me3 | CeRNA, Promoting EMT, Epigenetically silencing PTEN via recruiting EZH2 | |
CASC2 | Reversing | DDP | miR-19a | CeRNA, Promoting cell apoptosis | [136] |
HOTAIR | Inducing | DDP, 5-FU, ADM, MMC, PTX | miR-17-5p, PTEN, miR-217, miR-34a, PI3K/AKT, Wnt/β-catenin miR-126 | CeRNA, Promoting EMT, Regulating MDR-related genes, Inhibiting cell apoptosis, Promoting cell proliferation | |
THOR | Inducing | DDP | SOX9 | Increasing cancer stemness | [141] |
BLACAT1 | Inducing | OXA | miR-361, ABCB1 | CeRNA, Inhibiting apoptosis and promoting invasion, Regulating MDR-related genes | [142] |
GHET1 | Inducing | DDP | BAK, BCL-2, MDR1, MRP1 | Inhibiting cell apoptosis, Regulating MDR-related genes | [143] |
ANRIL | Inducing | 5-FU, DDP | MDR1, MRP1 | Regulating MDR-related genes | [144] |
UCA1 | Inducing | ADM, DDP, 5-FU | PARP, BCL-2, miR-27b, caspase-3 | CeRNA, Inhibiting cell apoptosis | |
PVT1 | Inducing | PTX, 5-FU, DDP | BCL-2, MDR1, MRP1, mTOR, HIF-1α | Inhibiting cell apoptosis | |
MRUL | Inducing | ADM, VCR | ABCB1 | Inhibiting cell apoptosis | [149] |
SNHG5 | Inducing | DDP | BCL-2, BAX, MDR1, MRP1 | Inhibiting cell apoptosis, Regulating MDR-related genes | [150] |
DANCR | Inducing | DDP | MDR1, MRP1 | Inhibiting cell apoptosis, Regulating MDR-related genes | [151] |
FAM84B-AS | Inducing | DDP | FAM84B, caspase3, caspase7, caspase9, BCL2, BCL-xL | Inhibiting cell apoptosis | [152] |
BCAR4 | Inducing | DDP | Wnt/β-catenin, Nanog, OCT3/4, SOX2, c-Myc, KLF4 | Increasing cancer stemness | [153] |
NEAT1 | Inducing | ADM | N/A | Inhibiting cell apoptosis, Promoting invasion | [154] |
LEIGC | Reversing | 5-FU | CDH1, E-cad, Vimentin, Twist, Slug, ZEB1, Snail | Inhibiting EMT | [155] |
CASC9 | Inducing | ADM, PTX | MDR1 | Inhibiting cell apoptosis, Promoting cell proliferation | [156] |
HOTTIP | Inducing | DDP, ADM, 5-FU | E-cad, ZO1, N-cad, Vimentin, ZEB1, Twist | Promoting EMT | [157] |
HCP5 | Inducing | OXA, 5-FU | MiR-3619-5p, SOX2, OCT4, LIN28, CD1331 | CeRNA, Increasing cancer stemness | [158] |