Skip to main content
Fig. 4 | Molecular Cancer

Fig. 4

From: METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

Fig. 4

SOX4 is a downstream target of METTL14. a. MeRIP-Seq and RNA-Seq identidied differentially expressed genes in METTL14 stable knockdown cells when compared with their corresponding controls. b, c. The mRNA b and protein c levels of SOX4 in METTL14-deficient HCT116 and HCT8 cells were detected using qRT-PCR and western blot, respectively. d. Expression of SOX4 mRNA in the TCGA cohort. e. The METTL14 mRNA expression levels in 136 CRC tissues and matched normal tissues were detected using qRT-PCR. f. Representive images of IHC staining for SOX4 protein on a tissue microarray constructed from 136 CRC tissues and matched normal tissues. g. The correlation between METTL14 and SOX4 in CRC. ***P < 0.001

Back to article page