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Fig. 1 | Molecular Cancer

Fig. 1

From: Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells

Fig. 1

circSATB2 promotes proliferation, migration and invasion of NCSLC cells. a circSATB2 expression in normal and lung cancer cells. b Genomic location and splicing mode of circSATB2. c Identification of circSATB2 qPCR amplification products. DNA gel electrophoresis (left) and Sanger sequencing of qPCR product (right). d GFP-tagged lentivirus in cells observed by fluorescence microscope. e Efficiency of stably transfected circSATB2-knockdown and overexpressing H460 cells detected by qPCR. f EdU assay to detect proliferation of circSATB2-knockdown and overexpressing stably transfected H460 and A549 cells. g, h Quantitative analysis of EdU assay. i Wound healing assay to detect migration of circSATB-knockdown and overexpressing stably transfected H460 and A549 cells. j Transwell migration assay detect migration of circSATB-knockdown and overexpressing stably transfected H460 and A549 cells. k Quantitative analysis of wound healing assay. (l) Quantitative analysis of Transwell migration assay. m Transwell invasion assay to detect invasion of circSATB2 knockdown and overexpressing stably transfected H460 and A549 cells. n, o Quantitative analysis of Transwell invasion assay. All experiments were repeated independently three times. Data are presented as means±standard deviation. **P < 0.01 compared with BAES-2B cells or lv3 group; ##P < 0.01 compared with lv5 group

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