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Fig. 1 | Molecular Cancer

Fig. 1

From: Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

Fig. 1

CircUHRF1 is upregulated in HCC tissues. a Heatmap showing UHRF1 gene-derived circRNAs in HCC tissues compared with matched adjacent nontumor tissues analyzed by qRT-PCR. b Schematic illustration of circUHRF1. c Differential expression of circUHRF1 in HCC tissues and adjacent nontumor tissues of 240 patients. d CircUHRF1 levels in 240 pairs of HCC and matched adjacent nontumor tissues, shown as log2 (T/N). e A total of 240 patients were divided into ≤5 cm and > 5 cm size groups. The diagram shows circUHRF1 expression in each group. f A total of 240 patients were divided into groups based on NK cell proportion in the blood (≤ 8% and > 8%). The diagram shows circUHRF1 expression in each group. g A total of 240 patients were divided into groups with or without microvascular invasion. The diagram shows circUHRF1 expression in each group. h and i Kaplan-Meier analysis of overall survival and recurrence in 240 patients with HCC according to circUHRF1 expression (log-rank test). Data are presented as the means ± SD of three independent experiments. **P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598