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Fig. 2 | Molecular Cancer

Fig. 2

From: Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

Fig. 2

Characterization of exosomes and the expression of circUHRF1. a High-resolution transmission electron microscopy image of HCC cell exosomes (scale bar = 200 nm). b The expression of exosomal biomarkers in HCC cell-derived exosomes was detected by western blot. c CircUHRF1 expression in HCC cell-derived exosomes was measured by qRT-PCR analysis. d circUHRF1 expression in HCC cells was measured by qRT-PCR analysis. e Exosomal circUHRF1 expression in the serum of healthy donors, patients before surgery, patients after surgery, and patients with recurrence. f A negative correlation between circUHRF1 expression in plasma exosomes and the proportion of NK cells was observed in HCC patient blood (R2 = 0.2040; P < 0.001). The data are presented as the mean ± SD; n = 3, *P < 0.05, **P < 0.01

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Molecular Cancer

ISSN: 1476-4598