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Fig. 3 | Molecular Cancer

Fig. 3

From: Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

Fig. 3

Exosomal expression of circUHRF1 inhibits the function of NK cells. a Schematic diagram of the coculture model. b and c HCC cells inhibit NK cell secretion of IFN-γ and TNF-α. d HCC cells upregulate the expression of circUHRF1 in NK cells. e GW4869 inhibits HCC cell-induced circUHRF1 upregulation in NK cells. f and g The effect of GW4869 on HCC-induced IFN-γ and TNF-α secretion by NK cells. h CircUHRF1 silencing is accompanied by decreased exosomal circUHRF1. i and j Decreased exosomal circUHRF1 promotes HCC-induced IFN-γ and TNF-α secretion by NK cells. The data are presented as the mean ± SD; n = 3, *P < 0.05, **P < 0.01, NS: not significant

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Molecular Cancer

ISSN: 1476-4598