Fig. 1
From: The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs
Dynamic and reversible m6A process. The installation, removal and identification of m6A are conducted by writers, readers, and erasers, respectively. Writers refer to the m6A complex, including METTL3, METTL14, WTAP, RBM15/15B, VIRMA and ZC3H13. Besides, METTL16 is a novel independent RNA methyltransferase. Erasers are proteins that own demethylases activity, including FTO, ALKBH5, ALKBH3. Readers are proteins that recognize the m6A modification and perform multiple functions in RNA metabolism, some of which identified so far are YTH family, HNRNP family, eIF3, IGF2BPs and Prrc2a