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Fig. 1 | Molecular Cancer

Fig. 1

From: RETRACTED ARTICLE: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p

Fig. 1

circTLK1 is overexpressed in RCC tissues and expression is significantly correlated with poor prognosis. a The cluster heat maps show the 10 most increased circRNAs between 293T cells and ACHN, 786-O, and 769-P cells. b Relative expression of circTLK1 in RCC cell lines compared to expression in 293T cells. c circTLK1 expression in RCC tissues was increased compared to expression in matched normal tissues. d circTLK1 expression in RCC patients with no metastasis and distant metastasis. e and f Kaplan-Meier analysis of the overall survival and disease-free survival of RCC patients with high and low expression of circTLK1. g Schematic illustration showing the production of circTLK1 through the circularization of exons 9 and 10 in TLK1. h circTLK1 was detected by RT-PCR, and its sequence was proven by Sanger sequencing. The black arrow displays the special splicing junction of circTLK1. i Relative expression of circTLK1 and TLK1 in ACHN cells was measured by a qRT-PCR assay upon RNase R treatment. *p < 0.05, **p < 0.01

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