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Fig. 6 | Molecular Cancer

Fig. 6

From: RETRACTED ARTICLE: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p

Fig. 6

CBX4 knockdown inhibits the proliferation, migration and invasion of RCC cells. a qRT-PCR assay was conducted to verify the expression of CBX4 in RCC cells transfected with shRNA targeting CBX4. b and c The growth curves of RCC cells transfected with shCBX4 were detected by using a CCK-8 assay. d and e Colony-formation assays were performed to measure the proliferation of RCC cells after CBX4 silencing. f and g Cell migration was examined in RCC cells transfected with shCBX4 or shNC by a wound healing assay. h and i Cell invasion was detected in RCC cells transfected with shCBX4 or shNC by a transwell assay. j Comprehensive transcriptional analysis indicated that CBX4 expression was significantly positively correlated with VEGFA expression in RCC tissues. k Knockdown of CBX4 suppressed the mRNA and protein expression of VEGFA. *p < 0.05, **p < 0.01

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Molecular Cancer

ISSN: 1476-4598